01 - Preheat grill or large skillet to medium-high heat.
02 - Combine ground beef, salt, black pepper, garlic powder, and onion powder in a mixing bowl. Mix gently until just incorporated.
03 - Divide beef mixture into 12 equal portions and shape into small patties, making them slightly larger than the buns to account for shrinkage during cooking.
04 - Grill or cook patties for 2-3 minutes per side until browned and cooked to desired doneness.
05 - During the final minute of cooking, place a slice of cheese on each patty and cover the grill or skillet until melted.
06 - Slice slider buns in half, brush cut sides with melted butter, and toast on grill or skillet until golden brown.
07 - Spread ketchup, mustard, and mayonnaise on bottom buns. Place cheeseburger patties on top, add pickles and red onion slices, and finish with top bun. Sprinkle with sesame seeds if desired.
08 - Serve sliders immediately while hot.